ABSTRACT
1]. To analyze of serum tumor marker CA-125 in patients with ovarian malignant tumors. 2]. To correlate between the serum levels of tumor marker with histological types of ovarian malignant tumors. Institution based descriptive and prospective study. Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro from January 2009 to June 2011. One hundred cases, diagnosed as ovarian malignant tumor on H and E staining were selected for study and measure serum CA-125 preoperatively and postoperatively in each case. Out of 100 cases diagnosed as on H and E stain were 33 serous cystadenocarcinoma, 24 mucinous adenocarcinoma, 10 germ cell tumors and 08 sex-cord stromal tumors. On serum analysis increased level of CA-125 was seen preoperatively in 33/33 cases of serous cystadenocarcinoma and 24/29 cases of mucinous adenocarcinoma. Serum tumor marker value was declined following appropriate therapy of the tumors. Serum tumor markers CA-125 is useful and important for the detection of ovarian tumors. It is most significant for serous cystadenocarcinoma. It may also help in prognosis and specific treatment of ovarian malignancies relating to histological type